My horse presented with atypical hives on his belly, patches of swelling, and overall angry/inflamed skin out of the blue. Luckily, I keep EquiShield IBH spray and salve stocked in my barn at all times exactly for this reason! I used the IBH spray for this case being the reactions covered several large areas and in 24 hours, his skin was back to normal with no swelling or hives! Plus, I was able to treat topically one time and did not need any additional interventions!